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Related Experiment Video

Updated: Jan 30, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Circulating angiogenic cell response to sprint interval and continuous exercise.

Louis O'Carroll¹, Bruce Wardrop¹, Ronan P Murphy²

¹Department of Sport and Exercise Science, Waterford Institute of Technology, Waterford, Ireland.

European Journal of Applied Physiology

|January 24, 2019

Summary

This summary is machine-generated.

Sprint interval exercise significantly boosts circulating angiogenic cells more than continuous exercise. This exercise-induced increase in angiogenic T lymphocytes (TANG) and Tie2-expressing monocytes (TEM) is temporary, highlighting the benefits of high-intensity training.

Keywords:

Angiogenic T cells Endothelial progenitor cells High intensity exercise Tie2 expressing monocytes

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Published on: October 10, 2019

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A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

Published on: February 22, 2022

Area of Science:

Exercise physiology
Cardiovascular health
Cellular biology

Background:

Certain T lymphocyte and monocyte subsets possess angiogenic potential, aiding blood vessel growth and repair.
These cells are responsive to exercise, potentially contributing to its cardiovascular benefits.

Purpose of the Study:

To compare the effects of continuous endurance exercise (CONTEX) and sprint interval exercise (SPRINT) on circulating angiogenic cells (CAC).
To investigate changes in specific CAC subsets, including angiogenic T lymphocytes (TANG) and Tie2-expressing monocytes (TEM).

Main Methods:

Twelve healthy adults underwent both 45-min CONTEX and SPRINT protocols in a counterbalanced design.
Blood samples were collected pre-exercise, and at 2, and 24 hours post-exercise.
Flow cytometry was used to quantify CAC subsets, including TANG (CD3+CD31+) and TEM (Tie2+).

Main Results:

Both exercise types increased circulating TANG cells immediately post-exercise, with SPRINT showing a significantly greater increase (57%) than CONTEX (14%).
SPRINT exercise led to transient increases in TEM and progenitor cells, while CONTEX did not.
Increased CXCR4 expression on TANG cells was observed 24 hours post-exercise in both conditions.

Conclusions:

Acute exercise, particularly high-intensity SPRINT, transiently elevates circulating angiogenic cells, including TANG, TEM, and progenitor cells.
Sprint interval exercise demonstrates a more pronounced effect on these angiogenic cell populations compared to continuous endurance exercise.
These findings suggest that high-intensity interval training may have a greater impact on vascular repair mechanisms than prolonged moderate-intensity exercise.