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Related Experiment Video

Updated: Jan 30, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Miles Berger1,2,3, Deborah Oyeyemi1,4, Mobolaji O Olurinde5

  • 1Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina.

Journal of the American Geriatrics Society
|January 24, 2019
PubMed
Summary
This summary is machine-generated.

This study investigates neuroinflammation

Keywords:
deliriummonocytemonocyte chemoattractant protein 1neuroinflammationpostoperative cognitive dysfunction

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Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Immunology

Background:

  • Postoperative cognitive dysfunction (POCD) and delirium affect up to 40% of older adults undergoing surgery, leading to reduced quality of life and increased mortality.
  • Neuroinflammation is a hypothesized underlying cause for both POCD and delirium, potentially increasing Alzheimer's disease risk.

Purpose of the Study:

  • To determine the association between postoperative increases in cerebrospinal fluid (CSF) monocyte chemoattractant protein 1 (MCP-1) and monocyte levels with delirium and POCD.
  • To investigate the impact of neuroinflammation on brain connectivity changes in older surgical patients.

Main Methods:

  • An observational prospective cohort study of 200 patients aged 60+ undergoing noncardiac/nonneurologic surgery.
  • Cognitive testing, delirium screening, and collection of blood and CSF samples at multiple time points.
  • Functional MRI and intraoperative EEG to assess brain connectivity and neuroinflammation correlates; sleep apnea testing included.

Main Results:

  • This section is not available in the provided abstract.

Conclusions:

  • The INTUIT study employs a transdisciplinary approach to explore neuroinflammation's role in postoperative cognitive changes.
  • Findings may identify novel therapeutic targets for preventing and treating delirium and POCD.