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Chitosan Microgels and Nanoparticles via Electrofluidodynamic Techniques for Biomedical Applications
Vincenzo Guarino1, Rosaria Altobelli2, Luigi Ambrosio3
1Institute for Polymers, Composites and Biomaterials, Department of Chemical Sciences & Materials Technology, National Research Council of Italy, Mostra D'Oltremare, Pad.20, V.le Kennedy 54, Naples 80125, Italy. vguarino@unina.it.
Gels (Basel, Switzerland)
|January 25, 2019
Summary
Electrofluidodynamics techniques (EFDTs) efficiently create chitosan microgels and nanoparticles. These versatile systems are suitable for various biomedical applications, including drug and cell delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Chemical Engineering
Background:
- Electrofluidodynamics techniques (EFDTs) utilize electrical forces for liquid atomization, producing particles from micrometers to nanometers.
- These particles exhibit scalable properties, making them attractive for diverse applications compared to bulk materials.
- Chitosan-based systems are explored for biomedical uses due to their biocompatibility and biodegradability.
Purpose of the Study:
- To optimize EFDTs for designing chitosan microgels and nanoparticles.
- To evaluate the suitability of these chitosan systems for biomedical applications.
- To investigate the morphology and size characteristics of EFDT-produced chitosan particles.
Main Methods:
- Optimization of Electrofluidodynamics techniques (EFDTs).
- Fabrication of chitosan microgels and nanoparticles.
- Morphological analysis using Optical Microscopy, Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM).
Main Results:
- EFDTs were successfully optimized for chitosan system fabrication.
- Chitosan particles were produced across a range of micro and nano-sizes.
- Microscopy confirmed the morphology of the chitosan microgels and nanoparticles.
Conclusions:
- EFDTs offer a versatile and feasible method for producing chitosan micro/nanoparticles.
- These chitosan systems demonstrate potential as carriers for cells and drugs in biomedical applications.
- The scalability and tunable size of EFDT-produced particles are key advantages.
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