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Updated: Jan 30, 2026

Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering
Published on: September 19, 2011
Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering
Antonella Sgambato1, Laura Cipolla2, Laura Russo3
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy. antonella.sgambato@unimib.it.
Abstract:
Disease, trauma, and aging account for a significant number of clinical disorders. Regenerative medicine is emerging as a very promising therapeutic option. The design and development of new cell-customised biomaterials able to mimic extracellular matrix (ECM) functionalities represents one of the major strategies to control the cell fate and stimulate tissue regeneration. Recently, hydrogels have received a considerable interest for their use in the modulation and control of cell fate during the regeneration processes. Several synthetic bioresponsive hydrogels are being developed in order to facilitate cell-matrix and cell-cell interactions. In this review, new strategies and future perspectives of such synthetic cell microenvironments will be highlighted.
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