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Related Experiment Video

Updated: Jan 30, 2026

In Vitro Ovule Cultivation for Live-cell Imaging of Zygote Polarization and Embryo Patterning in Arabidopsis thaliana
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Advances in ovulation trigger strategies.

Carlos Dosouto1,2, Thor Haahr3,4, Peter Humaidan3,4

  • 1Department of Obstetrics, Gynecology and Reproductive Medicine, Santa Creu I Sant Pau Hospital, Puigvert Foundation, Barcelona, Spain - cdosouto@fundacio-puigvert.es.

Panminerva Medica
|January 25, 2019
PubMed
Summary
This summary is machine-generated.

Choosing the right ovulation trigger (OT) is key for successful in-vitro fertilization (IVF). This review examines different OT agents and strategies to optimize IVF outcomes while minimizing risks like ovarian hyperstimulation syndrome.

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Area of Science:

  • Reproductive Medicine
  • In-Vitro Fertilization (IVF)
  • Endocrinology

Background:

  • Ovulation trigger (OT) strategies are crucial for personalized in-vitro fertilization (IVF) treatments.
  • Effective OT selection ensures optimal oocyte yield and quality, impacting fertilization and embryo development.
  • OT choice influences decisions regarding fresh or frozen embryo transfer (freeze-all) and minimizes risks like ovarian hyperstimulation syndrome (OHSS).

Purpose of the Study:

  • To review and evaluate various ovulation trigger (OT) strategies used in modern IVF.
  • To discuss the biological rationale and clinical evidence supporting different OT agents.
  • To provide guidance on selecting appropriate OT strategies for diverse clinical scenarios in IVF.

Main Methods:

  • Literature review of scientific publications on ovulation trigger agents and strategies in IVF.
  • Analysis of clinical evidence and biological plausibility for common OT agents, including human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone agonist (GnRH-a).
  • Evaluation of OT strategies in different patient populations and clinical contexts.

Main Results:

  • Human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone agonist (GnRH-a) are the most frequently used OT agents in IVF.
  • No single OT agent is universally superior; optimal choice depends on individual patient factors and treatment protocols.
  • Evidence supports tailored OT strategies for maximizing mature oocyte retrieval and improving IVF success rates.

Conclusions:

  • The selection of an appropriate ovulation trigger (OT) is a critical component of individualized IVF treatment.
  • A thorough understanding of the efficacy and safety profiles of different OT agents is essential for clinicians.
  • Optimizing OT strategies can lead to improved reproductive outcomes and reduced risks in assisted reproductive technologies.