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Diabetes Is a Risk Factor for Inflatable Penile Prosthesis Infection: Analysis of a Large Statewide Database

Michael J Lipsky1, Ifeanyi Onyeji1, Ron Golan2

  • 1Department of Urology, New York Presbyterian Hospital/ Columbia University Medical Center, New York, NY, USA.

Sexual Medicine
|January 25, 2019
PubMed
Abstract

Insights

Diabetes mellitus (DM) increases the risk of inflatable penile prosthesis (IPP) infection. This study confirms DM as a risk factor, impacting patient selection and counseling for IPP surgery.

Area of Science:

  • Urology
  • Andrology
  • Infectious Disease

Background:

  • The association between diabetes mellitus (DM) and inflatable penile prosthesis (IPP) infection is debated.
  • High-quality population-based evidence linking DM to increased IPP infection risk is lacking.

Purpose of the Study:

  • To investigate the association between DM and IPP infection.
  • Utilized a large public New York state database for analysis.

Main Methods:

  • Analyzed data from the New York Statewide Planning and Research Cooperative System (SPARCS) database (1995-2014).
  • Identified diabetic patients using ICD-9-CM codes and excluded those with prior IPP surgery.
  • Employed Chi-squared analyses and multivariate Cox proportional hazards models to assess DM's independent association with IPP infection across different eras.

Main Results:

  • 14,969 patients underwent initial IPP insertion; overall infection rate was 2.3%.
  • Diabetic patients had a higher infection rate (3%) compared to non-diabetics (2%) (P < .001).
  • DM independently increased IPP infection risk (Hazard Ratio: 1.32, P = .016) after controlling for covariates.

Conclusions:

  • Diabetes mellitus is confirmed as a significant risk factor for inflatable penile prosthesis infection.
  • Findings have implications for patient selection, counseling, and suggest exploring glycemic control optimization.
  • Further research may investigate mitigating DM-related IPP infection risks.
Keywords:
DiabetesErectile DysfunctionIPPInfectionPenile Implant

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