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Updated: Jan 30, 2026

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
Published on: January 29, 2020
Five-year nationwide incidence of macular hole requiring surgery in Korea
Soo Chang Cho1,2, Sang Jun Park1, Seong Jun Byun1
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Background/Aims:
To estimate the incidence and demographics of macular hole (MH) requiring surgery in Korea.
Methods:
Patients who underwent surgery for MH in Korea from 2011 to 2015 with the diagnostic code for MH and the surgical code for vitrectomy were retrospectively identified using the Korean national health claims database. The average incidence rate of MH during the 5-year study period was estimated by applying the direct method of standardisation using the 2015 census data as a reference population.
Results:
A total of 7301 patients with MH requiring surgery were identified. The average incidence of MH requiring surgery was 3.14 (95 % CI, 3.07 to 3.21) per 100 000 person-years . The incidence in women (4.29 per 100 000 person-years; 95% CI, 4.17 to 4.40) was significantly higher than that in men (2.00 per 100 000 person-years; 95% CI, 1.92 to 2.07; p<0.001). The incidence rate of MH increased exponentially with increasing age between the ages of 35 years and 69 years and was highest among patients aged 65-69 years. The female-to-male ratio for the incidence of MH was 2.15:1.
Conclusions:
This study represents the largest nationwide population-based investigation of the incidence of MH, using a database that covers the entire population of South Korea. MH is the disease of elderly peaked 70 years old and more common in women.
Insights
The incidence of macular hole (MH) surgery in Korea is 3.14 per 100,000 person-years, with higher rates in women and older adults. This population-based study highlights key demographics for surgical macular hole (MH) intervention.
Area of Science:
- Ophthalmology
- Public Health
- Epidemiology
Background:
- Macular hole (MH) is an eye condition requiring surgical intervention.
- Understanding the incidence and demographics of MH is crucial for healthcare planning.
Purpose of the Study:
- To estimate the incidence and demographic characteristics of patients undergoing surgery for macular hole (MH) in Korea.
- To provide population-based data on MH surgical needs.
Main Methods:
- Retrospective analysis of the Korean national health claims database (2011-2015).
- Identification of patients with diagnostic and surgical codes for MH and vitrectomy.
- Calculation of average incidence rates using direct standardization with 2015 census data.
Main Results:
- A total of 7,301 patients with MH requiring surgery were identified.
- The average incidence of MH surgery was 3.14 per 100,000 person-years.
- Incidence was significantly higher in women (4.29) than men (2.00) and increased with age, peaking in the 65-69 age group.
Conclusions:
- This study is the largest nationwide population-based investigation of MH incidence in South Korea.
- Macular hole (MH) is more prevalent in elderly individuals, particularly women.
- The findings underscore the demographic trends of MH requiring surgical intervention.
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