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Updated: Jan 30, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Anaphylaxis to patent blue dye in a 17-year-old boy
Mélanie Leung1, Christine McCusker2, Moshe Ben-Shoshan3
1Department of Medicine, McGill University, Montreal, Quebec, Canada.
Abstract:
Patent blue V dye (PBV) is frequently used as a perioperative drug for lymphangiography, as well as a food additive. Hypersensitivity to PBV is poorly documented in adults and had not been previously described in children. The diagnosis of PBV allergy depends on corroboration of history consistent with an IgE-mediated reaction and confirmatory skin tests. We present in this paper a paediatric case of PBV anaphylaxis and of biphasic reaction that exemplifies the challenges involved in diagnosing and managing this rare but potentially life-threatening allergic reaction.
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