Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced-fit Model01:13

Induced-fit Model

89.2K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.0K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.6K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.8K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.8K
Induced Electric Fields01:23

Induced Electric Fields

4.6K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.6K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

2.3K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The potential bidirectional relationship between long COVID and menstruation.

Nature communications·2025
Same author

Incorporating Menstruation Across Hospital Specialties to Improve Care for Women of Reproductive Age.

British journal of hospital medicine (London, England : 2005)·2025
Same author

COVID-19 and abnormal uterine bleeding: potential associations and mechanisms.

Clinical science (London, England : 1979)·2024
Same author

Technical Review of Clinical Outcomes Assessments Across the Continuum of Alzheimer's Disease.

Neurology and therapy·2023
Same author

Assessing What Matters to People Affected by Alzheimer's Disease: A Quantitative Analysis.

Neurology and therapy·2023
Same author

The Menstrual Endometrium: From Physiology to Future Treatments.

Frontiers in reproductive health·2022

Related Experiment Video

Updated: Jan 30, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K

Phenytoin-induced hypothermia.

Marianne Watters1, Hilary Wilson1, Pamela Everitt1

  • 1Department of Rheumatology, Glasgow Royal Infirmary, Glasgow, UK.

BMJ Case Reports
|January 25, 2019
PubMed
Summary

This case study highlights a rare instance of hypothermia potentially induced by high phenytoin levels in a patient with epilepsy. As phenytoin levels normalized, body temperature improved, suggesting a link.

Area of Science:

  • Neurology
  • Clinical Pharmacology

Background:

  • Phenytoin is a widely used antiepileptic drug.
  • Hypothermia is a serious condition with various potential causes.
  • Drug-induced toxicity can present with diverse and sometimes unexpected symptoms.

Observation:

  • A 60-year-old male with cerebral palsy and epilepsy presented with lethargy and poor coordination.
  • The patient was found to be hypothermic (35°C) upon admission.
  • Toxic levels of phenytoin were detected during routine laboratory work-up.

Findings:

  • No other cause for the hypothermia was identified.
  • The patient's body temperature gradually improved as phenytoin levels returned to normal.
  • This case adds to a small number of reported instances linking phenytoin toxicity to hypothermia.
Keywords:
drug interactionsepilepsy and seizuresunwanted effects / adverse reactions

More Related Videos

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.5K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.7K

Related Experiment Videos

Last Updated: Jan 30, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.5K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.7K

Implications:

  • Phenytoin toxicity should be considered in patients presenting with unexplained hypothermia, especially those on the medication.
  • This case underscores the importance of therapeutic drug monitoring for phenytoin.
  • Further investigation may be warranted to elucidate the mechanism of phenytoin-induced hypothermia.