Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

844
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
844
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

814
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
814
Classifying Matter by Composition03:35

Classifying Matter by Composition

90.3K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.3K
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

556
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
556

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone Fusion in the Cervical Spine: Where Are We Now?

Bioengineering (Basel, Switzerland)·2026
Same author

3D Bioprinting of High-Grade Serous Ovarian Cancer Cells: Workflow for Gelatin-Based Bioink Formulation with Hyaluronic Acid and Printability Assessment.

ACS applied bio materials·2026
Same author

Multi-institutional international investigation of VMAT treatment planning techniques for breast cancer with regional lymph nodes.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Harnessing Hydrogel Interaction with Functional Polymeric Nanoparticles for Sustained Co-Delivery of Therapeutics.

ACS biomaterials science & engineering·2026
Same author

Hydrogels for the treatment of spinal cord injury: progress and promise.

Nanomedicine (London, England)·2026
Same author

Stromal Vascular Fraction Across Different Clinical Indications: A Pro-Regenerative <i>Fil Rouge</i>.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jan 30, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K

Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery.

Emanuele Mauri1, Anna Negri2, Erica Rebellato3

  • 1Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy. emanuele.mauri@polimi.it.

Gels (Basel, Switzerland)
|January 25, 2019
PubMed
Summary

Biodegradable nanoparticles (NPs) were loaded into hydrogels (HG) to control drug release for central nervous system applications. Release rates depend on NP charge and HG pore size, enabling tailored drug delivery devices.

Keywords:
drug deliveryhydrogelpolymeric nanoparticlesrelease system

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.6K
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.5K

Related Experiment Videos

Last Updated: Jan 30, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.6K
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

16.5K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biodegradable poly(ethylene glycol)-block-poly(-lactic acid) (PEG-b-PLA) nanoparticles (NPs) offer potential for biomedical applications.
  • Hydrogels (HG) are widely explored for central nervous system (CNS) applications due to their biocompatibility and tunable properties.

Purpose of the Study:

  • To develop and characterize composite hydrogel-nanoparticle systems for controlled drug delivery.
  • To investigate the influence of nanoparticle surface charge and hydrogel mesh size on drug release kinetics.

Main Methods:

  • Nanoparticle preparation via nanoprecipitation with controlled dimensions and electric charges.
  • Loading of nanoparticles into hydrogels with varying pore sizes (30 and 90 nm).
  • In vitro release studies of a drug mimetic and diffusion studies of nanoparticles, analyzed using mathematical modeling.

Main Results:

  • Controlled release of a drug mimetic was achieved from the hydrogel-NP system.
  • Nanoparticle release kinetics were significantly influenced by their superficial charge and the hydrogel's mean mesh size.
  • Different release trends were observed based on the interplay between NP charge and HG pore size.

Conclusions:

  • The study successfully developed composite hydrogel-nanoparticle systems for tunable drug delivery.
  • Mathematical modeling rationalized release mechanisms, enabling the design of devices for specific medical needs.
  • The findings highlight the potential of these systems for advanced CNS drug delivery applications.