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Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange
Jacob R Lindale1, Shannon L Eriksson1, Christian P N Tanner1
1Department of Chemistry, Duke University, Durham, NC, 27708, USA.
Nature Communications
|January 25, 2019
Summary
Pulsing the excitation field in Signal Amplification by Reversible Exchange (SABRE) hyperpolarization enhances nuclear spin signals. New methods improve the efficiency of para-hydrogen utilization for hyperpolarization.
Area of Science:
- Magnetic Resonance Imaging
- Quantum Chemistry
- Physical Chemistry
Background:
- Signal Amplification by Reversible Exchange (SABRE) is a key technique for hyperpolarizing nuclear spins.
- Current SABRE methods achieve significant signal amplification for applications in imaging and spectroscopy.
- Optimized polarization transfer to heteronuclei like 13C and 15N is crucial for advanced applications.
Purpose of the Study:
- To investigate the impact of pulsed excitation fields on SABRE dynamics.
- To develop more efficient hyperpolarization sequences by optimizing para-hydrogen order utilization.
- To improve the overall efficiency of the SABRE technique.
Main Methods:
- Developed a Monte Carlo simulation approach to analyze coherent polarization transfer dynamics.
- Investigated pulsing the excitation field with varying duty cycles.
- Designed and tested improved SABRE sequences.
Main Results:
- Pulsing the excitation field, particularly with a low duty cycle (~1%), generates more magnetization than continuous excitation.
- Existing SABRE methods show inefficiencies in utilizing para-hydrogen order.
- The study presents novel sequences that enhance hyperpolarization efficiency.
Conclusions:
- Pulsed excitation offers a more effective strategy for SABRE hyperpolarization compared to continuous methods.
- Optimizing the use of para-hydrogen order is critical for maximizing SABRE efficiency.
- The developed methods and sequences promise significant improvements in hyperpolarized applications.
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