Related Experiment Video
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03:37
Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
Published on: June 6, 2025
463
Use case driven evaluation of open databases for pediatric cancer research
Fleur Jeanquartier1,2, Claire Jean-Quartier2, Andreas Holzinger1,2
11Institute of Interactive Systems and Data Science, Graz University of Technology, Graz, Austria.
Biodata Mining
|January 25, 2019
Summary
Limited pediatric cancer data exists online. This study evaluates 11 pediatric cancer resources, finding significant variation in data quantity and features, highlighting the need for improved childhood cancer research tools.
Area of Science:
- Oncology
- Bioinformatics
- Data Science
Background:
- Numerous web resources exist for cancer research, including large projects like the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA).
- However, openly available data specifically for childhood cancer research is scarce.
- Existing biomedical resources are often not tailored for pediatric or cancer-specific analyses.
Purpose of the Study:
- To summarize and compare open web resources supporting fundamental research in pediatric cancer.
- To evaluate 11 identified pediatric cancer-specific resources (5 tools, 6 databases).
Main Methods:
- A comparative evaluation of 11 pediatric cancer resources was conducted.
- Five use cases based on brain tumor research were employed.
- Methods included user-defined searches, data mining tasks, and assessment of interactive visualization features.
Main Results:
- Web resources vary significantly in data quantity and presentation.
- Pediatric Cancer Browser (Pecan) and Pediatric Cancer BioPortal offer visual analysis tools and integrate consortia data.
- UCSC Xena Browser and ICGC data portal provide in-depth genomic analysis, though ICGC focuses on adult cancers.
Conclusions:
- Web resources for pediatric cancer are less abundant and recognized than those for adult cancers.
- Ongoing data collection and Pan-Cancer projects offer future potential for childhood cancer research.
- Improved resources are crucial for both fundamental and clinical pediatric cancer research.
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