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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Genetic and environmental risk factors for chronic kidney disease

Gregorio T Obrador1, Ulla T Schultheiss2,3, Matthias Kretzler4,5

  • 1Department of Epidemiology, Biostatistics and Public Health, Universidad Panamericana School of Medicine, Mexico City, Mexico.

Kidney International Supplements
|January 25, 2019
PubMed

Insights

Understanding the genetic and environmental factors of chronic kidney disease (CKD) is crucial for developing new treatments. This review identifies knowledge gaps and proposes goals to advance CKD research and patient care.

Area of Science:

  • Nephrology
  • Genetics
  • Environmental Health

Background:

  • Chronic kidney disease (CKD) poses a significant global health challenge.
  • Current knowledge of CKD's genetic and environmental causes and their interactions is incomplete.
  • Advancing CKD therapeutics requires a deeper understanding of underlying disease mechanisms.

Purpose of the Study:

  • To review existing knowledge gaps concerning the genetic and environmental etiology of CKD.
  • To outline essential goals, timelines, and stakeholders for future CKD research.
  • To identify novel therapeutic and preventive targets for CKD.

Main Methods:

  • Literature review of current research on CKD causes.
  • Analysis of knowledge gaps in genetic and environmental factor interactions.
  • Formulation of research objectives and strategic planning.

Main Results:

  • Identified critical gaps in understanding the interplay between genetic predispositions and environmental exposures in CKD.
  • Proposed a framework for future research with defined objectives and timelines.
  • Highlighted the potential for new therapeutic strategies based on improved etiological insights.

Conclusions:

  • Addressing knowledge deficits in CKD's multifactorial causes is paramount.
  • Strategic research initiatives are necessary to close identified gaps.
  • Enhanced understanding will facilitate the development of novel interventions for CKD.
Keywords:
chronic kidney diseaseenvironmentgenetic kidney diseasegeneticsgenome-wide association studies

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