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Related Experiment Videos

Multiple intracranial aneurysms in identical twins.

S M Weil1, A Olivi, A L Greiner

  • 1Department of Neurosurgery, University of Cincinnati, Ohio.

Acta Neurochirurgica
|January 1, 1988
PubMed
Summary

Identical twins with intracranial aneurysms show a strong genetic link. If one twin has a subarachnoid hemorrhage, screening the other is recommended due to shared aneurysm risks.

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Area of Science:

  • Neurology
  • Genetics
  • Neurosurgery

Background:

  • Familial intracranial aneurysms (IAs) are recognized, with strong concordance among siblings.
  • Previous reports detail five pairs of identical twins experiencing subarachnoid hemorrhage (SAH).

Observation:

  • This report presents the sixth pair of identical twins diagnosed with multiple IAs.
  • The cases are unique as the first documented instance of multiple mirror aneurysms in identical twins.
  • One twin presented with SAH, while her asymptomatic sister underwent elective angiography.

Findings:

  • The asymptomatic twin revealed multiple IAs in identical locations to her affected sister.
  • This highlights a significant genetic predisposition and potential for concordant aneurysm development in identical twins.

Implications:

  • The findings suggest that genetic factors play a crucial role in IA development, particularly in identical twins.
  • Recommending diagnostic cerebral angiography for asymptomatic twins in families with a history of IA or SAH is clinically appropriate.
  • Early detection through screening can potentially prevent SAH and improve patient outcomes.

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