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Bisphosphonate-induced orbital inflammation: more common than once thought?
L K Chehade1,2, D Curragh3, D Selva3
1South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, Australia. Lkchehade@gmail.com.
Summary
Bisphosphonate medications can cause rare orbital inflammation. Early recognition and topical steroid treatment are key for successful management of this condition.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Bisphosphonates are commonly prescribed for osteoporosis and bone-related disorders.
- Orbital inflammation is a rare but increasingly recognized adverse effect of bisphosphonate therapy.
Observation:
- Two new cases of bisphosphonate-induced orbital inflammation are presented.
- One case involved risedronate re-challenge, and the other involved zoledronic acid.
- Both patients presented with suggestive clinical features of orbital inflammation.
Findings:
- Both cases were successfully managed with topical steroids.
- The clinic-radiological features and management options were discussed.
- The frequency of this association appears to be increasing.
Implications:
- Clinicians should be aware of the potential for bisphosphonate-induced orbital inflammation.
- Prompt ophthalmological referral is crucial for patients with suggestive symptoms.
- Early diagnosis and treatment can lead to favorable outcomes.
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