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Updated: Jan 30, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Nephron progenitor commitment is a stochastic process influenced by cell migration.

Kynan T Lawlor1, Luke Zappia1,2, James Lefevre3

  • 1Murdoch Children's Research Institute, Parkville, Australia.

Elife
|January 25, 2019
PubMed
Summary
This summary is machine-generated.

Nephron progenitor cells in mice can move back and forth between self-renewal and commitment states. This cellular plasticity is crucial for kidney development and adaptation within the dynamic nephrogenic niche.

Keywords:
Wnt4cell migrationdevelopmental biologykidney developmentmousenephron progenitorregenerative medicinesingle cell transcriptional profilingstem cellsstochastic induction

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Genetics

Background:

  • Tissue microenvironments provide spatial cues regulating progenitor cell behavior.
  • Nephrogenesis, the formation of kidney structures, involves progenitor self-renewal and differentiation.

Purpose of the Study:

  • To investigate how progenitor cell migration influences cell fate commitment within the mouse nephrogenic niche.
  • To understand the dynamic regulation of nephrogenesis.

Main Methods:

  • Utilized mouse models to study progenitor cell behavior.
  • Employed single-cell RNA sequencing (scRNA-seq) to analyze gene expression.
  • Applied computational modeling to interpret cell dynamics.

Main Results:

  • Identified a subset of cells expressing Wnt4 (a nephron commitment marker) that migrate back into the progenitor pool.
  • Observed accumulation of these returning cells over time.
  • Demonstrated that nephron progenitors can transition bidirectionally between self-renewal and commitment states.

Conclusions:

  • Progenitor cell migration plays a significant role in regulating cell fate within the nephrogenic niche.
  • Cellular plasticity allows nephron progenitors to switch between self-renewal and commitment.
  • This plasticity supports robust nephrogenesis in a remodeling organ environment.