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"Plug-n-Play" Sensing with Digital Microfluidics.

Richard P S de Campos1,2, Darius G Rackus1,2, Roger Shih1,2

  • 1Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.

Analytical Chemistry
|January 25, 2019
PubMed
Summary
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Plug-and-play digital microfluidics (PnP-DMF) overcomes sensor limitations by allowing rapid sensor exchange. This enhances flexibility for diverse applications, from blood analysis to multi-analyte detection.

Area of Science:

  • Microfluidics
  • Sensor Technology
  • Analytical Chemistry

Background:

  • Digital microfluidics (DMF) offers reconfigurable fluidic operations on a generic device.
  • Integrating embedded sensors compromises DMF's inherent flexibility.
  • A gap exists between DMF's adaptability and the need for diverse sensing capabilities.

Purpose of the Study:

  • Introduce plug-and-play digital microfluidics (PnP-DMF) to bridge the flexibility gap.
  • Demonstrate PnP-DMF's proof of concept using various interchangeable sensors.
  • Explore PnP-DMF's potential for complex analyses and multi-modal sensing.

Main Methods:

  • Designed DMF devices for rapid, seamless sensor exchange.
  • Utilized commercial biosensors (glucose, β-ketone), a custom paper-based sensor (lactate), and a screen-printed electroanalytical cell.

Related Experiment Videos

  • Integrated PnP sensors with electrochemical and chemiluminescent immunoassay techniques.

    • Main Results:

    • Successfully demonstrated PnP-DMF with multiple sensor types, enabling 'hot-swapping'.
    • Achieved automated blood sample analysis via standard addition using PnP-DMF.
    • Reported the first simultaneous analysis of different analytes in supernatant and precipitate from a single microfluidic sample aliquot, combining glucose and insulin detection.

    Conclusions:

    • PnP-DMF effectively restores and enhances the flexibility of digital microfluidics.
    • The PnP-DMF platform facilitates complex, automated analytical processes.
    • PnP-DMF shows significant versatility for diverse applications in diagnostics and beyond.