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Assessment and clinical relevance of the dynamic parameters of ventricular repolarization in patients with grade I

Antoinette Oliveira Blackman1,2,3, José Sobral Neto2, Melchior Luiz Lima1

  • 1a Instituto Cardiovascular São Francisco de Assis - Hospital Servcor, Belo Horizonte, MG, Brazil.

Canadian Journal of Physiology and Pharmacology
|January 25, 2019
PubMed

Insights

Asymptomatic patients with early diastolic dysfunction show altered ventricular repolarization and heart rate variability, indicating increased cardiovascular risk. These findings help identify high-risk individuals early.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Autonomic Nervous System Function

Background:

  • Ventricular repolarization abnormalities increase arrhythmia and sudden cardiac death risk.
  • Early detection markers for at-risk patients are limited.
  • Left ventricular diastolic dysfunction (LVDD) is a common cardiac condition.

Purpose of the Study:

  • To evaluate the impact of Grade I LVDD on ventricular repolarization and heart rate variability in asymptomatic individuals.
  • To identify potential early markers for cardiovascular risk in patients with LVDD.

Main Methods:

  • A 12-lead Holter monitor was used to assess QT dispersion, its circadian variation, and heart rate variability (HRV) in time and frequency domains.
  • Ambulatory patients with Grade I LVDD were compared to a control group.

Main Results:

  • 30% of patients with LVDD exhibited QT dispersion greater than 80 ms.
  • Statistically significant differences were observed in standard deviation of normal-to-normal intervals and low-frequency power between groups.
  • A minority of patients with LVDD presented with premature ventricular complexes exceeding 10/h.

Conclusions:

  • Increased ventricular repolarization parameters and reduced HRV suggest autonomic imbalance in asymptomatic Grade I LVDD patients.
  • These electrophysiological changes can identify individuals at higher risk for cardiovascular events.
  • Early assessment of repolarization and HRV may aid in risk stratification for LVDD patients.

Keywords:
QT intervalarythmie cardiaquecardiac arrhythmiadysfonctionnement ventriculaireechocardiography Dopplerheart rate variabilityintervalle QTvariabilité de la fréquence cardiaqueventricular dysfunctionéchocardiographie doppler

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