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Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
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Acute Pharyngitis01:30

Acute Pharyngitis

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Introduction
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Classification
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Acute Respiratory Failure-I01:21

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Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
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Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
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Acute Respiratory Failure-V01:29

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The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
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Employing Aeroponic Systems for the Clonal Propagation of Cannabis
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Acute cannabis toxicity.

Matthew J Noble1, Katrina Hedberg2, Robert G Hendrickson1

  • 1a Department of Emergency Medicine, Oregon Poison Center , Oregon Health & Science University , Portland , OR , USA.

Clinical Toxicology (Philadelphia, Pa.)
|January 25, 2019
PubMed
Summary
This summary is machine-generated.

Acute cannabis exposure, particularly from edibles, led to neurotoxicity in all age groups. Children faced unintentional exposures with severe outcomes, while concentrated products increased toxicity risks.

Keywords:
Marijuanacannabisoverdosepoisoningtoxicity

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Area of Science:

  • Toxicology
  • Public Health
  • Pharmacology

Background:

  • Recreational cannabis legalization presents new public health challenges.
  • Understanding acute cannabis exposure effects is crucial for harm reduction.
  • Poison control centers are key in managing acute intoxications.

Purpose of the Study:

  • To describe clinical effects and associated products of acute cannabis exposures.
  • To analyze differences in exposure patterns and outcomes across age groups.
  • To inform public health strategies during early cannabis legalization.

Main Methods:

  • Observational study using Oregon/Alaska Poison Center data (Dec 2015 - Apr 2017).
  • Standardized data collection on product details, exposure route, dose, and clinical outcomes.
  • Inclusion criteria: acute cannabis exposure calls; exclusion: chronic exposure, co-ingestants, non-humans.

Main Results:

  • 253 individuals acutely exposed; edibles were the most common product causing symptoms.
  • Children: unintentional ingestion of homemade edibles, leading to sedation.
  • Adults: intentional ingestion of retail edibles, leading to neuroexcitation.
  • Adolescents: mixed patterns; concentrated products increased toxicity, especially ingestions.

Conclusions:

  • Neurotoxicity is a common outcome of acute cannabis exposure.
  • Children are vulnerable to unintentional exposures with potential for severe adverse events.
  • Concentrated cannabis products pose a higher toxicity risk, necessitating targeted prevention strategies.