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Fluoroquinolone-Resistant Streptococcus agalactiae Invasive Isolates Recovered in Argentina

Bárbara Arias1, Verónica Kovacec1, Laura Vigliarolo2

  • 11 Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología, Biotecnología y Genética, Cátedra de Microbiología, Buenos Aires, Argentina.

Microbial Drug Resistance (Larchmont, N.Y.)
|January 25, 2019
PubMed

Insights

Fluoroquinolone resistance in Group B Streptococcus (GBS) is a growing concern, with a study in Argentina finding 14.8% resistance. This resistance is linked to a specific clone, highlighting the need for ongoing surveillance of GBS antibiotic susceptibility.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Group B Streptococcus (GBS) is a significant pathogen affecting neonates and nonpregnant adults.
  • Epidemiological data on GBS fluoroquinolone (FQ) resistance in Latin America is limited.
  • Invasive GBS infections necessitate understanding antimicrobial resistance patterns.

Purpose of the Study:

  • To determine the prevalence of FQ resistance in invasive GBS isolates in Argentina.
  • To investigate the genetic mechanisms, serotype distribution, and clonal spread of FQ-resistant GBS.
  • To contribute to the surveillance of GBS epidemiology and antibiotic susceptibility.

Main Methods:

  • Prospective multicenter collection of 162 invasive GBS isolates from July 2014 to July 2015.
  • Screening for FQ nonsusceptibility using a five-disc method and determining levofloxacin MIC.
  • Genetic analysis included sequencing of gyrA and parC genes, capsular typing, PFGE, and MLST.

Main Results:

  • A prevalence of 14.8% FQ resistance was observed among invasive GBS isolates.
  • All resistant isolates harbored point mutations in both gyrA and parC genes.
  • Serotype Ib was predominant (88%), with a single PFGE type (ST10) accounting for 84% of resistant isolates.

Conclusions:

  • The high rate of FQ resistance is likely driven by the dissemination of a specific ST10/serotype Ib clone.
  • Continuous surveillance of GBS epidemiology and antibiotic susceptibility is crucial.
  • Findings underscore the need to monitor antimicrobial resistance trends in GBS infections.

Keywords:
antibiotic resistanceepidemiologyfluoroquinolones

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