Related Experiment Video
Updated: Jan 30, 2026
10:50
Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
1.4K
Endoplasmic reticulum stress: a key player in human disease
1Cambridge Institute for Medical Research (CIMR), University of Cambridge, UK.
The FEBS Journal
|January 25, 2019
Summary
This Special Issue explores endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in various human diseases. It highlights their roles in conditions like myopathies, lung diseases, liver dysfunction, and neurodegenerative disorders, suggesting therapeutic potential.
Area of Science:
- Molecular Biology
- Cellular Biology
- Pathology
Background:
- Endoplasmic reticulum (ER) stress is implicated in numerous human diseases.
- The unfolded protein response (UPR) is a cellular pathway that responds to ER stress.
Purpose of the Study:
- To review the multifaceted roles of ER stress and UPR in diverse human pathologies.
- To explore the therapeutic potential of targeting the UPR.
Main Methods:
- This Special Issue compiles eleven expert reviews.
- The reviews synthesize current knowledge on ER stress and UPR in disease.
Main Results:
- ER stress and UPR are crucial in myopathies, lung diseases, liver dysfunction, and inflammatory responses.
- UPR modulation is relevant in neurodegenerative disorders and cancer.
Conclusions:
- Targeting the UPR presents a promising therapeutic strategy for various diseases.
- Understanding ER stress mechanisms is key to developing new treatments.
Related Concept Videos
01:39Endoplasmic Reticulum
107.8K
The Endoplasmic Reticulum (ER) in eukaryotic cells is a substantial network of interconnected membranes with diverse functions, from calcium storage to biomolecule synthesis. A primary component of the endomembrane system, the ER manufactures phospholipids critical for membrane function throughout the cell. Additionally, the two distinct regions of the ER specialize in the manufacture of specific lipids and proteins.
107.8K
01:43The Endoplasmic Reticulum
21.4K
The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
21.4K
01:21Smooth Endoplasmic Reticulum
8.0K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.0K
01:34Directing Proteins to the Rough Endoplasmic Reticulum
17.6K
The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
17.6K
01:19Key Techniques in Microbiology
2.3K
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
2.3K
02:35Key Elements for Plant Nutrition
24.2K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.2K