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Gastrointestinal Involvement in Patients with Mantle Cell Lymphoma: A Single Center Experience of Eighty-Five

Wolfgang Lamm1, Werner Dolak2, Barbara Kiesewetter3

  • 1Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria, wolfgang.lamm@meduniwien.ac.at.

Digestive Diseases (Basel, Switzerland)
|January 25, 2019
PubMed
Abstract

Insights

Gastrointestinal tract involvement is common in mantle cell lymphoma (MCL) but does not appear to impact prognosis or cause complications. Routine GI assessment is not recommended for MCL patients due to asymptomatic presentation.

Area of Science:

  • Oncology
  • Gastroenterology
  • Hematology

Background:

  • Gastrointestinal (GI) tract involvement in mantle cell lymphoma (MCL) is estimated at 30% but often asymptomatic.
  • Existing studies lack rigorous GI assessment, necessitating further investigation.
  • Standardized GI assessment at diagnosis prompted this study on MCL GI involvement.

Purpose of the Study:

  • To determine the frequency and prognostic significance of GI involvement in MCL patients.
  • To evaluate the clinical impact of GI involvement on the course of MCL.
  • To assess the necessity of routine GI assessment in MCL diagnosis.

Main Methods:

  • Retrospective single-center study of 85 consecutive MCL patients.
  • Data collected from clinical records, including endoscopic GI assessment.
  • Analysis of GI involvement rate, symptoms, and prognostic factors.

Main Results:

  • Endoscopically detectable GI involvement found in 34% of MCL patients.
  • Colon (72%) and stomach (28%) were most frequently affected.
  • No significant differences in gender, ECOG, or MIPI between groups; survival was not statistically impacted by GI involvement.

Conclusions:

  • GI involvement in MCL is frequent but generally asymptomatic.
  • No significant clinical impact or complications during chemotherapy observed.
  • Data suggest routine GI assessment may not be necessary for MCL patients.
Keywords:
EndoscopyGastrointestinal involvementMantle cell lymphoma

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