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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The successful treatment with ixekizumab in a multi-failure psoriasis patient

Alexandra Azevedo1, Tiago Torres

  • 1Department of Dermatology, Centro Hospitalar do Porto, Edifício das Consultas Externas, Rua D. Manuel II, s/n, Porto, Portugal. alexandrapmazevedo@gmail.co.

Dermatology Online Journal
|January 26, 2019
PubMed

We report a patient with severe psoriasis who failed to respond to phototherapy, conventional systemic treatment and four biologic agents (etanercept, ustekinumab, adalimumab and secukinumab). Combination of a higher-dose secukinumab regimen with phototherapy had no success. Remarkably, ixekizumab, an IL-17A inhibitor, provided almost complete psoriasis clearance after 24 weeks of treatment. The reason for the success of ixekizumab after the failure to respond to a biologic with same mechanism of action is still unknown. Interestingly, failure of secukinumab does not preclude future therapeutic success with a second IL-17A-inhibitor.

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