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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Mast Cells and Angiogenesis in Human Plasma Cell Malignancies
Domenico Ribatti1, Roberto Tamma2, Angelo Vacca3
1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy. domenico.ribatti@uniba.it.
International Journal of Molecular Sciences
|January 26, 2019
Summary
Mast cells promote angiogenesis in plasma cell malignancies by supporting tumor growth and therapeutic resistance. Targeting mast cells could offer a novel adjuvant therapy by inhibiting tumor-promoting factors and enhancing immune responses.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Bone marrow angiogenesis is crucial in hematological malignancy development and progression.
- Tumor microenvironments foster angiogenesis, proliferation, invasion, metastasis, and therapeutic resistance.
- Increased mast cell numbers are observed in angiogenesis linked to hematological tumors.
Purpose of the Study:
- To review the role of mast cells in angiogenesis within human plasma cell malignancies.
- To explore mast cells as a potential therapeutic target for these cancers.
Main Methods:
- Literature review focusing on mast cells and angiogenesis in plasma cell malignancies.
- Analysis of mast cell functions including cytokine secretion and immune modulation.
Main Results:
- Mast cells contribute to tumor angiogenesis, tissue remodeling, and secretion of tumor-promoting molecules.
- Mast cells can mediate immune suppression within the tumor microenvironment.
- Selective inhibition of mast cell pro-angiogenic activities is feasible.
Conclusions:
- Mast cells are implicated in the pathogenesis of plasma cell malignancies through angiogenesis.
- Targeting mast cells offers a potential strategy for adjuvant therapy by inhibiting angiogenesis and immune suppression.
- Modulating mast cell activity may enhance the efficacy of treatments for hematological tumors.
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