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Comparison between Exhaustive and Equilibrium Extraction Using Different SPE Sorbents and Sol-Gel Carbowax 20M Coated
Angela Tartaglia1, Marcello Locatelli2, Abuzar Kabir3
1Department of Pharmacy, University of Chieti⁻Pescara "G. d'Annunzio", Via dei Vestini 31, 66100 Chieti, Italy. angela.tartaglia@unich.it.
Molecules (Basel, Switzerland)
|January 26, 2019
Summary
This study compares extraction techniques for inflammatory bowel disease (IBD) drugs, finding novel sol-gel Carbowax 20M (CW 20M) media effective for simultaneous analysis. The research validates a new method for detecting these crucial IBD medications.
Area of Science:
- Analytical Chemistry
- Pharmacology
- Materials Science
Background:
- Inflammatory Bowel Disease (IBD) requires effective drug monitoring.
- Simultaneous analysis of IBD drugs with varying polarities presents a challenge.
- Novel extraction materials are needed to improve analytical efficiency.
Purpose of the Study:
- To compare exhaustive and equilibrium extraction methods for IBD drugs.
- To evaluate the performance of various solid phase extraction (SPE) sorbents and fabric phase sorptive extraction (FPSE) media.
- To characterize a novel sol-gel Carbowax 20M (CW 20M) SPE sorbent for simultaneous drug extraction.
Main Methods:
- Compared classical SPE sorbents (C18, HLB) and a novel sol-gel CW 20M SPE sorbent under exhaustive extraction.
- Utilized sol-gel CW 20M coated FPSE media under equilibrium extraction.
- Analyzed cortisone, ciprofloxacin, and sulfasalazine using HPLC with gradient elution.
- Validated the bioanalytical method according to international guidelines.
Main Results:
- The novel sol-gel CW 20M SPE sorbent demonstrated effective extraction capabilities.
- Characterization of the sol-gel CW 20M SPE sorbent included breakthrough volume, retention, and theoretical plates.
- The developed method allowed for the simultaneous extraction and analysis of three IBD drugs with different logP values.
Conclusions:
- The novel sol-gel CW 20M SPE sorbent is a promising material for the simultaneous extraction of IBD drugs.
- The study provides a validated bioanalytical method for IBD drug analysis.
- This research contributes to improved diagnostics and treatment monitoring for IBD patients.
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