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11β Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study
Ravindra Shukla1, Asish Kumar Basu2, Biplab Mandal2
1Department of Endocrinology & Metabolism, AIIMS, Jodhpur, 342005, India. ravindrashukla2@rediffmail.com.
BMC Endocrine Disorders
|January 26, 2019
Summary
Activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11β HSD 1) is elevated in type 2 diabetes, particularly in lean individuals. Fasting blood glucose is a key predictor of this enzyme’s activity.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Biochemistry
Background:
- Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder.
- 11 beta-hydroxysteroid dehydrogenase type 1 (11β HSD 1) plays a role in regulating cortisol bioavailability.
- Altered 11β HSD 1 activity may contribute to T2DM pathophysiology.
Purpose of the Study:
- To compare 11β HSD 1 activity in individuals with T2DM versus controls.
- To investigate the association between 11β HSD 1 activity and metabolic parameters in T2DM.
Main Methods:
- A case-control study involving 30 T2DM patients and 30 matched controls.
- Cortisone acetate test used to assess 11β HSD 1 activity.
- Measurements included serum cortisol, fasting blood glucose, BMI, and other metabolic markers.
Main Results:
- Elevated serum cortisol rise post-cortisone acetate administration in T2DM subjects.
- 11β HSD 1 activity correlated with exercise, BMI, and SGOT, but not calorie intake, lipids, or thyroid status.
- Fasting blood glucose is a strong predictor of 11β HSD 1 activity.
Conclusions:
- 11β HSD 1 activity is higher in T2DM, especially in lean individuals.
- 11β HSD 1 inhibitors may benefit T2DM patients with elevated fasting blood glucose.
- Further research on DHEAS and vitamin D status in relation to 11β HSD 1 is warranted.
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