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Prevalence, Presentation, and Associated Conditions of Patients With Fibromuscular Dysplasia

Chayakrit Krittanawong1, Anirudh Kumar2, Kipp W Johnson3

  • 1Department of Internal Medicine, Icahn School of Medicine at Mount Sinai St' Luke and Mount Sinai West Hospitals, New York, New York.

The American Journal of Cardiology
|January 26, 2019
PubMed

Insights

Fibromuscular dysplasia (FMD) is a rare vascular disease. This study found FMD primarily affects women and has low in-hospital mortality, often presenting with hypertension.

Area of Science:

  • Vascular Medicine
  • Epidemiology
  • Internal Medicine

Background:

  • Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease causing arterial narrowing.
  • The population-based prevalence and clinical characteristics of FMD are not well-established.

Purpose of the Study:

  • To evaluate the prevalence, clinical presentation, mortality, and associated conditions of FMD.
  • To identify key demographic and clinical features of FMD patients.

Main Methods:

  • Retrospective analysis of the National Inpatient Sample database.
  • Inclusion of patients diagnosed with FMD between January 1, 2004, and September 30, 2015.
  • Evaluation of patient demographics, presenting symptoms, and in-hospital outcomes.

Main Results:

  • FMD was identified in 2,420 patients, with 86.20% being female.
  • The most common presenting symptoms included hypertension (67.3%), transient ischemic attack (3.7%), and headache (2.1%).
  • In-hospital mortality for FMD patients was low at 0.74%.

Conclusions:

  • FMD is a rare condition predominantly affecting women.
  • Hypertension is the most frequent clinical presentation of FMD.
  • FMD is associated with low in-hospital mortality, suggesting a need for increased consideration in female patients with hypertension.

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