Related Experiment Video
Updated: Jan 30, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Interest of pharmacoepidemiology for the study of antibiotic drugs
1Service de pharmacologie médicale et clinique, UMR INSERM 1027, CIC INSERM 1436, faculté de médecine, centre hospitalier universitaire, 37, allées Jules-Guesde, 31000 Toulouse, France.
Abstract:
Antibiotics (ABs) exposure of population is known as the main driving force for the emergence and spread of bacterial resistance in the community. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs. Thus, pharmacoepidemiology is particularly of interest to monitor ABs use in both hospital and community settings. This can help to better understanding determinants of ABs use and to evaluate their impact. ABs use can also be a marker of an infection, which can be an ADR of other drugs. The development of pharmacoepidemiology should improve the "rational use" of ABs.
Related Concept Videos
Antibiotic Selection
Development of Antibiotic Resistance
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Pharmacokinetics: Drug–Drug Interactions
Bioequivalence of Drugs: Drugs with Multiple Indications

