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Updated: Jan 30, 2026
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Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures MAAC
Published on: February 13, 2020
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Adipocyte Mineralocorticoid Receptor.
Marco Infante1, Andrea Armani2, Vincenzo Marzolla2
1Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, ASL Roma 2, University Tor Vergata, Rome, Italy.
Vitamins and Hormones
|January 26, 2019
Summary
Mineralocorticoid receptor (MR) overactivation in fat tissue worsens metabolic syndrome. Blocking MR prevented obesity in mice, but human studies are needed to confirm benefits for weight gain and metabolic health.
Area of Science:
- Endocrinology
- Metabolic Research
- Obesity Science
Background:
- Mineralocorticoid receptor (MR) is present in adipose tissue.
- Excessive MR activation in fat contributes to metabolic syndrome and obesity-related derangements.
- A cross-talk exists between adipose tissue and adrenal glands, potentially causing hyperaldosteronism.
Purpose of the Study:
- To investigate the role of MR antagonism in obesity and metabolic syndrome.
- To evaluate the metabolic effects of MR antagonists in clinical settings.
Main Methods:
- Review of recent findings on MR in adipose tissue.
- Analysis of murine models of genetic and diet-induced obesity treated with MR antagonists.
- Identification of knowledge gaps regarding clinical applications.
Main Results:
- MR blockade prevented weight gain and improved metabolic parameters in murine obesity models.
- Evidence suggests a link between adipose MR activation and obesity-related hyperaldosteronism.
Conclusions:
- Pharmacological MR blockade shows promise for managing obesity and metabolic syndrome in preclinical models.
- Larger clinical trials are essential to determine the efficacy and safety of MR antagonists in humans for these conditions.
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