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Updated: Jan 30, 2026
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Solution Blow Spinning of Polymeric Nano-Composite Fibers for Personal Protective Equipment
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Nano-radiogold-decorated composite bioparticles
Agata Wójtowicz1, Pamela Krug1, Paulina Głowala1
1University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.
Summary
Hybrid bioparticles loaded with gold nanoparticles show promise for cancer therapy. Combining radioactive gold-198 and doxorubicin demonstrated significant synergistic antitumor effects on breast cancer cells in vitro.
Area of Science:
- Biotechnology
- Nanomedicine
- Materials Science
Background:
- Development of novel drug delivery systems for enhanced cancer therapy.
- Utilizing bacterial templates for nanoparticle synthesis.
- Exploring synergistic effects of combined therapeutic agents.
Purpose of the Study:
- To prepare hybrid composite bioparticles using Lactobacillus rhamnosus and gold nanoparticles.
- To evaluate the therapeutic potential of these biocomposites, including radioactive gold-198, against cancer cells.
- To investigate the synergistic effect of the biocomposite and doxorubicin on breast cancer cells.
Main Methods:
- Preparation of gold nanoparticles within Lactobacillus rhamnosus cells.
- Characterization using microscopic, spectroscopic, and thermal techniques.
- In vitro testing of biocomposite efficacy on cancer cell cultures (MCF-7).
Main Results:
- Uniform distribution of 3.7 nm gold nanoparticles within bacterial cells and their hydrogel shell.
- Demonstration of therapeutic potential using beta-minus radiation from gold-198.
- Significant synergistic antitumor activity observed with the combination of beta-minus radiation and doxorubicin.
Conclusions:
- Hybrid composite bioparticles offer a novel platform for cancer therapy.
- The combination of radioactive gold nanoparticles and doxorubicin shows potent synergistic effects against breast cancer.
- This approach holds promise for developing new and effective anticancer treatments.
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