Does the RYGB common limb length influence hypertension remission and cardiometabolic risk factors? Data from the

Carlos Aurelio Schiavon1, Renato Nakagawa Santos1, Eliana Vieira Santucci1

  • 1Research Institute, Heart Hospital, Sao Paulo, Brazil.

Insights

Common limb length (CLL) in Roux-en-Y gastric bypass (RYGB) surgery does not impact hypertension remission or cardiometabolic health. This study found no significant correlation between varying CLL and patient outcomes after RYGB.

Area of Science:

  • Bariatric Surgery
  • Metabolic Surgery
  • Gastroenterology

Background:

  • Roux-en-Y gastric bypass (RYGB) is effective for weight loss and improving cardiometabolic risk factors.
  • However, the influence of common limb length (CLL) on these outcomes remains unclear.

Purpose of the Study:

  • To investigate the relationship between common limb length (CLL) and hypertension remission rates.
  • To assess correlations between CLL and cardiometabolic risk factors and nutritional parameters post-RYGB.

Main Methods:

  • A randomized trial (GATEWAY) compared RYGB to medical therapy over 1 year.
  • Patients had Roux-en-Y gastric bypass with a 150-cm alimentary limb and 100-cm biliopancreatic limb.
  • Statistical analyses included logistic regression and correlation tests to evaluate CLL's impact.

Main Results:

  • Of 45 RYGB patients completing follow-up, 55.6% achieved hypertension remission.
  • Common limb length (CLL) was not significantly associated with hypertension remission (OR: 0.97; P=0.88).
  • No significant correlations were found between CLL and changes in cardiometabolic risk factors or nutritional parameters.

Conclusions:

  • In proximal RYGB, common limb length (CLL) does not appear to influence hypertension remission.
  • CLL does not significantly affect cardiometabolic risk factors or nutritional parameters following RYGB.
Abstract

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
370
Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.1K
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
6.3K
Factors Influencing Attraction I: Proximity01:22

Factors Influencing Attraction I: Proximity

Proximity plays a fundamental role in shaping interpersonal attraction by increasing opportunities for interaction and fostering familiarity. Research consistently demonstrates that individuals are more likely to form social bonds with those who are physically closer to them, whether in residential settings, workplaces, or educational institutions. This effect is largely driven by the increased frequency of encounters, which facilitates the development of friendships and romantic...
267
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K