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Does the RYGB common limb length influence hypertension remission and cardiometabolic risk factors? Data from the
Carlos Aurelio Schiavon1, Renato Nakagawa Santos1, Eliana Vieira Santucci1
1Research Institute, Heart Hospital, Sao Paulo, Brazil.
Insights
Common limb length (CLL) in Roux-en-Y gastric bypass (RYGB) surgery does not impact hypertension remission or cardiometabolic health. This study found no significant correlation between varying CLL and patient outcomes after RYGB.
Area of Science:
- Bariatric Surgery
- Metabolic Surgery
- Gastroenterology
Background:
- Roux-en-Y gastric bypass (RYGB) is effective for weight loss and improving cardiometabolic risk factors.
- However, the influence of common limb length (CLL) on these outcomes remains unclear.
Purpose of the Study:
- To investigate the relationship between common limb length (CLL) and hypertension remission rates.
- To assess correlations between CLL and cardiometabolic risk factors and nutritional parameters post-RYGB.
Main Methods:
- A randomized trial (GATEWAY) compared RYGB to medical therapy over 1 year.
- Patients had Roux-en-Y gastric bypass with a 150-cm alimentary limb and 100-cm biliopancreatic limb.
- Statistical analyses included logistic regression and correlation tests to evaluate CLL's impact.
Main Results:
- Of 45 RYGB patients completing follow-up, 55.6% achieved hypertension remission.
- Common limb length (CLL) was not significantly associated with hypertension remission (OR: 0.97; P=0.88).
- No significant correlations were found between CLL and changes in cardiometabolic risk factors or nutritional parameters.
Conclusions:
- In proximal RYGB, common limb length (CLL) does not appear to influence hypertension remission.
- CLL does not significantly affect cardiometabolic risk factors or nutritional parameters following RYGB.
Background:
Although Roux-en-Y gastric bypass (RYGB) results in significant weight loss and cardiometabolic risk factors improvements; there is no consensus whether limb lengths may influence these results.
Objective:
To evaluate the correlations between the common limb length (CLL) and hypertension remission rate, cardiometabolic risk factors, and nutritional parameters after RYGB.
Settings:
Private Hospital, Brazil.
Methods:
GATEWAY is a randomized trial designed to evaluate the efficacy of RYGB on hypertension improvement and other cardiometabolic risk factors in patients with grade I and II obesity compared with medical therapy. The follow-up was 1 year. We measured the entire bowel in all patients and used a 150-cm alimentary limb and a 100-cm biliopancreatic limb. Univariate logistic regression was used to estimate the relationship between CLL and hypertension remission. Pearson and Spearman correlation were used to evaluate the correlation between the CLL and the percentage changes of cardiometabolic risk factors and nutritional parameters.
Results:
From 100 randomized patients, 45 were submitted to RYGB and completed the follow-up. Mean CLL was 466.3 ± 86.4 cm. Of patients, 55.6% from the RYGB group showed remission of hypertension. CLL length was not significantly associated with hypertension remission (odds ratio [95% confidence interval] for 50 units increase in CLL: .97 [.68; 1.38], P = .88). Consistently, we found no correlations between CLL and all changes in cardiometabolic risk factors and nutritional parameters.
Conclusions:
In a proximal RYGB, CLL does not influence hypertension remission, cardiometabolic risk factors, and nutritional parameters.
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