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Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Culture of Bladder Cancer Organoids as Precision Medicine Tools
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Introduction to precision medicine in COPD.

Janice M Leung1,2, Ma'en Obeidat1,2, Mohsen Sadatsafavi3

  • 1UBC Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.

The European Respiratory Journal
|January 26, 2019
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Summary

Precision medicine offers a tailored approach to treating chronic obstructive pulmonary disease (COPD), moving beyond one-size-fits-all care. Biomarkers are key to identifying patient subgroups and predicting treatment responses for better COPD management.

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Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Pharmacology

Background:

  • Chronic obstructive pulmonary disease (COPD) understanding has advanced, yet therapeutic innovation remains slow.
  • COPD is recognized as a heterogeneous disease with diverse phenotypes and endotypes.
  • Current COPD care often employs a "one-size-fits-all" approach, limiting treatment efficacy.

Purpose of the Study:

  • To discuss the concept of precision medicine in the context of COPD.
  • To highlight the need for personalized treatment strategies in COPD care.
  • To explore the implementation of precision medicine for global COPD patient populations.

Main Methods:

  • Review of current precision medicine concepts and their application to COPD.
  • Discussion of the role of biomarkers in personalized COPD treatment.
  • Exploration of strategies for implementing precision medicine in clinical practice.

Main Results:

  • Precision medicine enables tailored COPD treatment by considering individual variability.
  • Biomarkers are crucial for predicting treatment benefits, harm, and patient outcomes.
  • A shift towards precision medicine is necessary for effective COPD management.

Conclusions:

  • Precision medicine represents a paradigm shift for COPD treatment, moving from generalized to individualized care.
  • The strategic use of predictive, response, and prognostic biomarkers is essential for successful precision medicine implementation in COPD.
  • Implementing precision medicine can significantly improve therapeutic outcomes for millions of COPD patients worldwide.