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Initiation of coagulation by tissue factor.

¹Department of Medicine, Mt. Sinai Medical School, New York, New York.

CRC Critical Reviews in Biochemistry

|January 1, 1988

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Tissue factor (TF) initiates blood coagulation, a vital hemostatic process. This review covers TF

Area of Science:

Biochemistry
Hematology
Molecular Biology

Background:

Tissue factor (TF) is a key initiator of the coagulation cascade.
Its role in hemostasis is critical for preventing blood loss.
Understanding TF's function is essential for managing bleeding and clotting disorders.

Purpose of the Study:

To review the historical discovery and scientific basis of TF's role in coagulation.
To examine the structural and functional features of TF that enable its initiator function.
To explore the regulation of TF expression and its implications in thrombosis and hemorrhage.

Main Methods:

Review of historical studies on thromboplastic activity.
Analysis of research on TF purification and cDNA cloning.

Related Experiment Videos

Examination of kinetic models for TF-initiated clotting.

Investigation of factors controlling TF expression in cultured cells.

Main Results:

TF, a membrane glycoprotein, initiates coagulation by forming a complex with factor VII.
This complex formation occurs without prior proteolysis, highlighting TF's unique initiator role.
TF's structure and function are optimized for initiating the coagulation cascade.

Conclusions:

TF is the principal biological initiator of hemostasis.
Understanding TF regulation is crucial for addressing pathological conditions like thrombosis and hemorrhage.
Further research into TF's molecular mechanisms and expression control is warranted.