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Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Yuina Sonohara1, Junpei Yamamoto1, Kosuke Tohashi1

  • 1Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan.

Scientific Reports
|January 26, 2019
PubMed
Summary

Researchers identified a new DNA lesion caused by acetaldehyde, an environmental mutagen. This GG intrastrand crosslink may explain acetaldehyde's toxicity and mutagenicity in DNA.

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