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Unresponsive shock due to amlodipine overdose: An unexpected cause
Shailesh Kumar1, Devyani Thakur1, Ritesh Kumar Gupta1
1Department of Medicine, Dr RML Hospital and PGIMER, Delhi, India.
Journal of Cardiovascular and Thoracic Research
|January 26, 2019
Summary
Amlodipine overdose can cause severe shock and acute kidney injury. Prompt treatment with intravenous calcium and hyperinsulinemia-euglycemia therapy (HIET) can reverse these critical complications.
Area of Science:
- Cardiology
- Nephrology
- Clinical Toxicology
Background:
- Amlodipine, a dihydropyridine calcium channel blocker, is a common antihypertensive medication.
- Amlodipine overdose is infrequent but can lead to serious complications, including death.
- Refractory shock and acute kidney injury are critical manifestations of severe amlodipine toxicity.
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