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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Androgen receptor and soy isoflavones in prostate cancer

Monika Kmetová Sivoňová1, Peter Kaplán1,2, Zuzana Tatarková1

  • 1Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.

Molecular and Clinical Oncology
|January 26, 2019
PubMed

Insights

Soy isoflavones show promise in combating castration-resistant prostate cancer by targeting the androgen receptor (AR) signaling pathway. This review explores their potential as a dietary intervention for hormone-related cancers.

Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • Androgens and the androgen receptor (AR) are crucial in prostate development and cancer.
  • Androgen deprivation therapy (ADT) is a primary prostate cancer treatment, but resistance develops.
  • Castration-resistant prostate cancer (CRPC) remains a significant cause of mortality.

Purpose of the Study:

  • To review the anticancer potential of soy isoflavones against prostate cancer.
  • To elucidate the mechanisms by which soy isoflavones affect the androgen receptor (AR) signaling pathway.
  • To explore soy isoflavones as a potential therapeutic or preventative strategy for hormone-related cancers.

Main Methods:

  • Literature review of studies on soy isoflavones and prostate cancer.
  • Analysis of research investigating the interaction between soy isoflavones and the AR signaling pathway.
  • Synthesis of data on the effects of genistein, daidzein, and glycitein on AR activity.

Main Results:

  • Soy isoflavones, including genistein, daidzein, and glycitein, exhibit anticancer properties.
  • These compounds modulate the AR signaling pathway, offering a potential strategy against prostate cancer.
  • Evidence suggests a role for soy isoflavones in preventing or treating hormone-dependent cancers.

Conclusions:

  • Soy isoflavones possess significant anticancer potential, particularly in prostate cancer.
  • Targeting the AR pathway with soy isoflavones is a promising therapeutic avenue.
  • Dietary interventions with soy isoflavones warrant further investigation for cancer management.
Keywords:
androgen receptordaidzeingenisteinglyciteinprostate cancersoy isoflavonessteroids

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