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What is Genetic Engineering?

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Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Recent challenges and advances in genetically-engineered cell therapy.

Seok-Beom Yong^1,2, Jee Young Chung^1,2, Yoonsung Song^1,2

¹1Department of Bioengineering, Hanyang University, Seoul, 04763 Republic of Korea.

Journal of Pharmaceutical Investigation

|January 26, 2019

Summary

Gene modification enhances cell therapy by improving cell function. Advanced techniques like CRISPR/Cas9 offer potent future treatments by enabling precise genetic editing for stem and immune cells.

Keywords:

Cell therapy Gene engineering Gene-modified cell therapy Immune cell therapy Stem cell therapy

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Area of Science:

Biomedical Science
Regenerative Medicine
Immunotherapy

Background:

Cell therapy shows therapeutic potential but faces challenges.
Genetic modification can enhance cell function and overcome limitations.
CRISPR/Cas9 technology offers precise genome editing capabilities.

Purpose of the Study:

To review recent advancements in genetic modification for cell therapy.
To highlight the role of stem cells and immune cells in therapy.
To emphasize the future potential of gene-modified cell therapies.

Main Methods:

Review of current literature on gene editing techniques.
Focus on CRISPR/Cas9 for genetic modification.
Discussion of stem cell and immune cell applications.

Main Results:

Gene delivery improves cell function through gene silencing and expression.
CRISPR/Cas9 is a powerful tool for cellular modification.
Stem and immune cells are key candidates for gene-modified therapies.

Conclusions:

Gene-modification-based cell therapy represents a promising future treatment modality.
Further development is needed to fully realize the potential of these therapies.
Precise genetic editing is crucial for optimizing cell therapy outcomes.