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Updated: Jan 30, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
Published on: June 23, 2022
Delineating the tumor margin with intraoperative surface-enhanced Raman spectroscopy
Chunhuan Jiang1, Ying Wang2, Wei Song3
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.
Surface-enhanced Raman scattering (SERS) offers a sensitive method for precisely mapping tumor margins during surgery. This technique improves tumor resection accuracy, potentially reducing cancer recurrence and metastasis.
Area of Science:
- Biomedical Optics
- Surgical Oncology
- Spectroscopy
Background:
- Incomplete tumor resection is a primary driver of cancer recurrence and metastasis.
- Accurate intraoperative tumor margin delineation is challenging due to tumor infiltration and microscopic spread.
Purpose of the Study:
- To review the application of surface-enhanced Raman scattering (SERS) spectroscopy for intraoperative image-guided cancer resection.
- To highlight advancements in SERS tags and their design for improved surgical guidance.
Main Methods:
- Review of recent literature on SERS spectroscopy in surgical oncology.
- Analysis of SERS tag development and design principles.
- Discussion of SERS-based intraoperative navigation strategies.
Main Results:
- SERS demonstrates high sensitivity, specificity, and spatial resolution for depicting tumor extents.
- Successful development of SERS tags shows promise for precise tumor margin identification.
- SERS-based navigation can potentially enhance surgical precision and completeness.
Conclusions:
- SERS spectroscopy is a promising technology for improving intraoperative tumor margin assessment.
- Further development of SERS tags and navigation systems is crucial for clinical translation.
- SERS-based image-guided surgery holds potential to significantly improve cancer treatment outcomes.
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