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Updated: Jan 30, 2026

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
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Delineating the tumor margin with intraoperative surface-enhanced Raman spectroscopy

Chunhuan Jiang1, Ying Wang2, Wei Song3

  • 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.

Analytical and Bioanalytical Chemistry
|January 26, 2019
PubMed

Insights

Surface-enhanced Raman scattering (SERS) offers a sensitive method for precisely mapping tumor margins during surgery. This technique improves tumor resection accuracy, potentially reducing cancer recurrence and metastasis.

Area of Science:

  • Biomedical Optics
  • Surgical Oncology
  • Spectroscopy

Background:

  • Incomplete tumor resection is a primary driver of cancer recurrence and metastasis.
  • Accurate intraoperative tumor margin delineation is challenging due to tumor infiltration and microscopic spread.

Purpose of the Study:

  • To review the application of surface-enhanced Raman scattering (SERS) spectroscopy for intraoperative image-guided cancer resection.
  • To highlight advancements in SERS tags and their design for improved surgical guidance.

Main Methods:

  • Review of recent literature on SERS spectroscopy in surgical oncology.
  • Analysis of SERS tag development and design principles.
  • Discussion of SERS-based intraoperative navigation strategies.

Main Results:

  • SERS demonstrates high sensitivity, specificity, and spatial resolution for depicting tumor extents.
  • Successful development of SERS tags shows promise for precise tumor margin identification.
  • SERS-based navigation can potentially enhance surgical precision and completeness.

Conclusions:

  • SERS spectroscopy is a promising technology for improving intraoperative tumor margin assessment.
  • Further development of SERS tags and navigation systems is crucial for clinical translation.
  • SERS-based image-guided surgery holds potential to significantly improve cancer treatment outcomes.
Keywords:
Accurate delineationIntraoperative navigationSERS tagsSurface-enhanced Raman scattering (SERS)Tumor resection

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