[The expression and degradation of tissue thromboplastin]

The highest disintegration rate of FITC-thromboplastin occurred in the organs rich in RES-cells. The half-disintegration period was found to be 58 +/- 12 min in liver, 98 +/- 48 min in spleen, 262 +/- 36 min in kidneys, 310 +/- 114 min in lung microcirculatory flow. Several pathways were found of the thromboplastin tissue local disintegration mediated via proteolytic and lipolytic enzymes released from endothelial cells and leucocytes: endocytosis of RES-cells followed by intracellular cleavage by lysosomal enzymes; and gradual blood transfer of thromboplastin particles from the organs with moderate disintegration rate to the organs capable of rapid disintegration.