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Hashish smoking and T-lymphocytes.

E Kaklamani, D Trichopoulos, A Koutselinis

    Archives of Toxicology
    |April 27, 1978
    PubMed
    Summary

    Long-term hashish use did not impair T-lymphocyte response to phytohemagglutinin (PHA). A single hashish smoking session may even slightly stimulate lymphocytes in chronic users.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Toxicology

    Background:

    • Chronic hashish use is prevalent globally.
    • Understanding its immunological effects is crucial for public health.
    • T-lymphocytes play a key role in immune response.

    Purpose of the Study:

    • To investigate the impact of chronic hashish consumption on T-lymphocyte function.
    • To assess immediate effects of hashish smoking on immune parameters.

    Main Methods:

    • Measured 14C-thymidine incorporation in peripheral blood lymphocytes (unstimulated and PHA-stimulated).
    • Assessed E-rosette proportion and number in chronic users and controls.
    • Compared measurements before and after a hashish smoking session in users.

    Main Results:

    • Hashish smoking did not impair lymphocyte response to phytohemagglutinin (PHA) at the tested concentration.
    • A slight stimulatory effect on lymphocytes was observed in chronic users post-smoking.
    • No significant impairment in T-lymphocyte function was detected.

    Conclusions:

    • Hashish consumption, at the levels studied, does not appear to suppress T-lymphocyte activity.
    • Acute hashish smoking may potentially offer a mild stimulatory effect on immune cells.
    • Further research is warranted to explore long-term immunological consequences.

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