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Coordination-induced structural changes of DNA-based optical and electrochemical sensors for metal ions detection
Chunli Sun1, Xiaowen Ou, Yong Cheng
1State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering; Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering; National Engineering Research Center for Nanomedicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. chengy@hust.edu.cn.
Abstract:
Metal ions play a critical role in human health and abnormal levels are closely related to various diseases. Therefore, the detection of metal ions with high selectivity, sensitivity and accuracy is particularly important. This article highlights and comments on the coordination-induced structural changes of DNA-based optical, electrochemical and optical-electrochemical-combined sensors for metal ions detection. Challenges and potential solutions of DNA-based sensors for the simultaneous detection of multiple metal ions are also discussed for further development and exploitation.
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