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Cell type-specific structural plasticity of the ciliary transition zone in C. elegans
Jyothi S Akella1, Malan Silva1,2, Natalia S Morsci
1Department of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, 08854, USA.
Biology of the Cell
|January 26, 2019
Summary
The ciliary transition zone (TZ) in developing C. elegans sensory neurons shows structural plasticity, remodeling over time. This challenges the static model, revealing dynamic TZ development in metazoans.
Area of Science:
- Cell Biology
- Developmental Biology
- Microscopy
Background:
- The established model of cilia development suggests a static transition zone (TZ) structure formed by nine centrosomal microtubules.
- This model fails to explain observed structural variations and potential misinterpretation of ciliary phenotypes.
- Understanding in vivo TZ events during metazoan development is crucial.
Purpose of the Study:
- To investigate the dynamic structural changes of ciliary transition zones during development.
- To challenge the existing paradigm of a static TZ structure.
Main Methods:
- Characterization of sensory cilia ultrastructure in developing Caenorhabditis elegans.
- Analysis of cephalic male (CEM) and inner labial quadrant (IL2Q) sensory neurons.
Main Results:
- Ciliary TZs in CEM and IL2Q neurons exhibit structural plasticity, remodeling during development.
- The number of microtubule doublets in the TZ can increase or decrease, varying by cilia type.
- Structural TZ intermediates, distinct from adult forms, were observed during development.
Conclusions:
- The study extends the current model by incorporating structural plasticity of the metazoan transition zone.
- TZs can be developmentally delayed, maintained, or remodeled in a cell type-specific manner.
- This highlights dynamic regulation of TZ structure during organismal development.
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