Related Experiment Video
Updated: Jan 30, 2026
06:59
Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue
Published on: October 12, 2013
20.5K
More movement with evaluating colonic transit in humans.
Adil E Bharucha1, Bradley Anderson1, Michel Bouchoucha2,3
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Neurogastroenterology and Motility
|January 26, 2019
Summary
Assessing colonic transit is crucial for understanding gut disorders and treatment effects. New methods like the electromagnetic capsule offer detailed insights into colonic motor patterns without radiation.
Area of Science:
- Gastroenterology
- Physiology
- Medical Devices
Background:
- Colonic functions require complex transit patterns, with colonic transit time being a significant portion of overall gastrointestinal transit.
- Accurate colonic transit assessment is vital for diagnosing conditions like slow transit constipation and understanding disease pathophysiology.
- Current methods for colonic transit assessment include radiopaque markers, scintigraphy, pH-pressure capsule, and the newer electromagnetic capsule.
Purpose of the Study:
- To evaluate and compare existing and emerging methods for assessing colonic transit in humans.
- To assess the utility of the electromagnetic capsule for evaluating colonic motor patterns without radiation exposure.
- To identify future challenges in correlating colonic pressures, contractions, and transit.
Main Methods:
- Review of existing and evolving colonic transit assessment techniques.
- Evaluation of the electromagnetic capsule for assessing overall and regional colonic transit and motor patterns.
- Comparison of electromagnetic capsule findings with manometry for motor patterns.
Main Results:
- The electromagnetic capsule assesses colonic motor patterns via capsule movement characteristics (distance, velocity) without radiation.
- The electromagnetic capsule does not measure colonic pressures or wall contractions.
- Further research is needed to correlate pressures, contractions, and transit.
Conclusions:
- The electromagnetic capsule provides a novel, radiation-free method for analyzing colonic motor patterns.
- Integrating data from various techniques is necessary to fully understand the interplay of colonic pressures, contractions, and transit.
- Future research should focus on combining these methods for a comprehensive assessment of colonic function.
More Related Videos
Related Concept Videos
02:31Phase Transitions
23.1K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.1K
02:58Properties of Transition Metals
29.8K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.8K
01:58Cooperative Allosteric Transitions
8.7K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K
02:22The Colonization of Land
37.6K
Changes in the environment of the early Earth drove the evolution of organisms. As prokaryotic organisms in the oceans began to photosynthesize, they produced oxygen. Eventually, oxygen saturated the oceans and entered the air, resulting in an increase in atmospheric oxygen concentration, known as the oxygen revolution approximately 2.3 billion years ago. Therefore, organisms that could use oxygen for cellular respiration had an advantage. More than 1.5 years ago, eukaryotic cells and...
37.6K
02:39Phase Transitions: Vaporization and Condensation
21.0K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
21.0K
02:33Phase Transitions: Sublimation and Deposition
20.1K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
20.1K