Related Experiment Video

Updated: Jan 30, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

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Impact of calcification on percutaneous coronary intervention: MACE-Trial 1-year results

Samin K Sharma1, Ryan W Bolduan2, Manesh R Patel3

  • 1Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|January 26, 2019
PubMed

Insights

Severe calcification significantly impacts percutaneous coronary intervention outcomes. Moderate calcification, however, showed similar results to mild or no calcification in this prospective study.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Clinical Trials

Background:

  • Previous studies on coronary lesion calcification were limited by retrospective designs and lack of core lab evaluation.
  • The impact of moderate versus severe calcification on percutaneous coronary intervention (PCI) outcomes requires further investigation.

Purpose of the Study:

  • To evaluate the impact of moderate to severe coronary lesion calcification on procedural and long-term outcomes of percutaneous coronary intervention (PCI).
  • To address limitations of prior studies by employing a prospective, multicenter design with core lab assessment of calcification.

Main Methods:

  • Prospective, multicenter observational study (MACE-Trial) enrolling 350 subjects.
  • Core lab assessed lesion calcification: none/mild (133), moderate (99), severe (114).
  • Primary endpoints included lesion success, procedural success, and 1-year major adverse cardiac events (MACEs).

Main Results:

  • Severe calcification significantly reduced lesion success (83.3%) and procedural success (86.8%) compared to none/mild calcification.
  • One-year MACE rates increased with calcification severity: none/mild (4.7%), moderate (8.7%), severe (24.4%) (P < 0.001).
  • Severe calcification and decreasing estimated glomerular filtration rate (eGFR) were predictors of 30-day and 1-year MACE.

Conclusions:

  • Severe coronary calcification is associated with significantly worse PCI outcomes.
  • Unlike prior retrospective studies, moderate calcification did not result in significantly different outcomes compared to none/mild calcification.
  • This prospective data clarifies the distinct impact of varying degrees of coronary calcification on PCI success and MACE.
Abstract

Keywords:
atherectomycoronary artery calcificationpercutaneous coronary intervention

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