Left ventricular deformation in relation to the geometric pattern in hypertensive patients

Related Experiment Video

Updated: Jan 30, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

20.1K

Ting-Yan Xu1, Yan Yang, Jing-Jing Li

  • 1Shanghai Key Laboratory of Hypertension, Center for Vascular Evaluations, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Medicine
|January 26, 2019
PubMed

Insights

Hypertension alters left ventricular deformation, affecting different layers and orientations based on geometric patterns. Speckle tracking echocardiography reveals distinct strain changes in hypertensive patients with normal ejection fraction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular (LV) geometry changes are common in hypertension.
  • Understanding LV deformation in relation to geometric patterns is crucial for risk stratification.

Purpose of the Study:

  • To evaluate left ventricular (LV) deformation using speckle tracking echocardiography (STE) in hypertensive patients with normal ejection fraction.
  • To assess the relationship between LV geometric patterns and LV deformation in hypertension.
  • To investigate layer-specific and orientation-specific strain changes in hypertensive hearts.

Main Methods:

  • Transthoracic echocardiography and STE were performed in 80 hypertensive patients and 50 controls.
  • LV geometric patterns were classified based on LV mass index and relative wall thickness.
  • Quantitative measurements of longitudinal, circumferential, and radial strain were analyzed for endocardial, middle, and epicardial layers.

Main Results:

  • Longitudinal strain was reduced in concentric and eccentric hypertrophy, and in endocardial layer of concentric remodeling.
  • Circumferential strain varied: increased in normal geometry/concentric remodeling, decreased in concentric hypertrophy.
  • Radial strain and LV twist did not significantly differ between groups.

Conclusions:

  • Left ventricular deformation in hypertension is heterogeneous, varying with geometric patterns and affecting different myocardial layers.
  • STE can detect subtle, layer-specific, and orientation-dependent changes in LV function in hypertensive patients.
  • These findings highlight the complex interplay between hypertension, LV geometry, and myocardial mechanics.

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