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Updated: Jan 30, 2026
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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
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Non-alcoholic fatty liver disease (NAFLD), active component, U.S. Armed Forces, 2000-2017
MSMR
|January 26, 2019
Summary
Non-alcoholic fatty liver disease (NAFLD) diagnoses in service members surged 12-fold from 2000-2017. Rates increased across all demographics, with males, older individuals, and certain ethnic groups most affected. Metabolic comorbidities were common.
Area of Science:
- Hepatology
- Epidemiology
- Military Health
Background:
- Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern.
- Understanding NAFLD incidence trends in specific populations, like active-duty military personnel, is crucial for targeted interventions.
- Previous research has not fully elucidated the epidemiological trajectory of NAFLD within the US military.
Purpose of the Study:
- To determine the incidence and trends of non-alcoholic fatty liver disease (NAFLD) diagnoses in active component service members from 2000 to 2017.
- To analyze demographic disparities (sex, age, race/ethnicity) in NAFLD incidence.
- To examine the prevalence of metabolic comorbidities among service members diagnosed with NAFLD.
Main Methods:
- Retrospective analysis of incident non-alcoholic fatty liver disease (NAFLD) diagnoses.
- Utilized data from active component service members between 2000 and 2017.
- Calculated crude incidence rates per 100,000 person-years and analyzed trends by demographics and comorbidities.
Main Results:
- A total of 19,069 incident NAFLD diagnoses occurred, with an overall crude incidence rate of 77.7 cases per 100,000 person-years.
- Crude annual incidence rates increased 12-fold from 2000 to 2017, with higher rates in males, those aged 50+, and Asian/Pacific Islander and Hispanic individuals.
- Over two-thirds of NAFLD cases had metabolic comorbidities, with dyslipidemia, obesity/overweight, and hypertension being most prevalent. The percentage of cases with multiple comorbidities rose significantly.
Conclusions:
- Non-alcoholic fatty liver disease (NAFLD) incidence has dramatically increased among US active-duty service members.
- Significant demographic variations in NAFLD incidence exist, highlighting potential disparities.
- The high prevalence of metabolic comorbidities underscores the systemic nature of NAFLD and the need for comprehensive management strategies.
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