Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Splicing01:32

RNA Splicing

60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
3.6K
Alternative RNA Splicing02:18

Alternative RNA Splicing

25.1K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
25.1K
Alternative RNA Splicing02:18

Alternative RNA Splicing

5.1K
5.1K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.5K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Onconeural antigen NOVA1 dysregulates RNA alternative splicing in breast cancer.

RNA (New York, N.Y.)·2026
Same author

Global research landscape in pharmacotherapy for autism spectrum disorder core symptoms: a bibliometric study.

Translational pediatrics·2026
Same author

Searching for potential biosignatures in impact-induced hydrothermal systems on Mars.

Science bulletin·2026
Same author

Exon inclusion signatures enable accurate estimation of splicing factor activity.

Nature communications·2026
Same author

Single-cell RNA sequencing of adenoid cystic carcinoma of the breast reveals cellular heterogeneity and tumor microenvironment features.

BMC medical genomics·2026
Same author

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.

Nature communications·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

6.4K

The Splicing Code Goes Deep.

Suying Bao1, Daniel F Moakley1, Chaolin Zhang1

  • 1Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

Cell
|January 26, 2019
PubMed
Summary
This summary is machine-generated.

Genomic sequence context significantly impacts RNA splicing, generating transcriptome diversity. These findings highlight the crucial role of DNA sequence in regulating gene expression and cellular function.

More Related Videos

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.4K
Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.4K

Related Experiment Videos

Last Updated: Jan 30, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

6.4K
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.4K
Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.4K

Area of Science:

  • Molecular Biology
  • Genomics
  • Transcriptomics

Background:

  • RNA splicing is a critical post-transcriptional modification that generates transcriptome diversity.
  • The influence of genomic sequence context on RNA splicing has been an area of active investigation.

Purpose of the Study:

  • To elucidate the role of genomic sequence context in RNA splicing.
  • To understand how sequence context contributes to transcriptome diversity.

Main Methods:

  • Analysis of genomic sequences and their correlation with splicing patterns.
  • Comparative studies across different genomic contexts.

Main Results:

  • Genomic sequence context is a key determinant of RNA splicing outcomes.
  • Specific sequence elements within the genome influence alternative splicing events.
  • This context is crucial for generating the full spectrum of transcriptome diversity.

Conclusions:

  • Genomic sequence context plays a fundamental role in RNA splicing.
  • Understanding sequence-based regulation of splicing is essential for comprehending gene expression and cellular function.