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Roller compaction: Ribbon splitting and sticking.

Osama Mahmah1, M J Adams2, Chalak S Omar1

  • 1Department of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.

International Journal of Pharmaceutics
|January 26, 2019
PubMed
Summary
This summary is machine-generated.

Roller compaction splitting, a key issue in dry granulation, was studied. Lubrication and roller type significantly impact ribbon splitting, affecting tablet quality.

Keywords:
Ribbon splittingRoller compactionSticking

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Chemical Engineering

Background:

  • Roller compaction is a primary dry granulation method.
  • Ribbon splitting (transverse or longitudinal) and sticking to rollers are critical process limitations.
  • Splitting affects granule properties and final tablet performance.

Purpose of the Study:

  • To investigate the mechanisms of ribbon splitting during roller compaction.
  • To understand the influence of powder properties, roller surface, and lubrication on splitting.

Main Methods:

  • Experimental study using single-component powders with varying yield strengths.
  • Utilized smooth and knurled rollers, with and without magnesium stearate lubrication.
  • Varied maximum roll stress at a fixed minimum gap.

Main Results:

  • A splitting index was developed to rationalize trends for smooth rollers.
  • Transverse splitting decreased, while longitudinal splitting increased with higher splitting index values.
  • Lubrication prevented transverse splitting and associated sticking; knurled rollers showed splitting without sticking in some cases.

Conclusions:

  • Splitting mechanisms are influenced by residual stresses, powder tensile strength, and roller surface characteristics.
  • Lubrication is effective in mitigating transverse splitting and roller sticking.
  • Knurled rollers offer an alternative by reducing sticking, though splitting may still occur.