Related Experiment Video
Updated: Jan 30, 2026

Natural Product Discovery with LC-MS/MS Diagnostic Fragmentation Filtering: Application for Microcystin Analysis
Published on: May 31, 2019
Natural product derived privileged scaffolds in drug discovery
Emma K Davison1, Margaret A Brimble2
1School of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland, New Zealand.
Abstract:
The biological activity and structural diversity of natural products are unsurpassed by any available synthetic screening libraries. As such, these privileged scaffolds serve as important, biologically prevalidated platforms for the design of compound libraries in the search for new drug candidates. Recent progress has focussed on improving the potency, selectivity and pharmacokinetics of bioactive natural products through structural modification, leading to the emergence of a number of drug-like lead compounds. Here, we review recent advances in the exploitation of terpenoid, polyketide, phenylpropanoid and alkaloid natural product scaffolds for inspiration in the design and development of important new drug candidates.
More Related Videos
Related Concept Videos
Drug Discovery: Overview
Drug Product Stability
What is Natural Selection?
Drug Products: Biologics, Biosimilars and Interchangeables
Nature and Nurture
Drug Product Performance: In Vitro–In Vivo Correlation

