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Updated: Jan 30, 2026

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Long Non-Coding RNAs in Multiple Myeloma

Romana Butova1, Petra Vychytilova-Faltejskova2, Adela Souckova3

  • 1Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic. romanabutova@gmail.com.

Non-Coding RNA
|January 27, 2019
PubMed

Insights

Long non-coding RNAs (lncRNAs) play a crucial role in multiple myeloma (MM) pathogenesis. Further research into lncRNAs may reveal novel biomarkers for this hematooncological malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma (MM) is a significant hematooncological malignancy characterized by malignant plasma cells in the bone marrow.
  • Despite advancements in treatment, the precise pathogenesis of MM remains incompletely understood.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in the development and progression of various cancers, including MM.

Purpose of the Study:

  • To review the current understanding of non-coding RNAs (ncRNAs), with a specific focus on lncRNAs.
  • To elucidate the involvement and significance of lncRNAs in the pathogenesis of multiple myeloma.
  • To explore the potential of lncRNAs as diagnostic or prognostic biomarkers for MM.

Main Methods:

  • Literature review of existing research on ncRNAs and MM.
  • Analysis of studies investigating lncRNA expression and function in MM.
  • Synthesis of current knowledge regarding the biological roles of lncRNAs in MM development.

Main Results:

  • Over 15,000 human lncRNA molecules have been identified, exhibiting diverse functions and cell-specific distributions.
  • lncRNAs are implicated in fundamental biological processes such as proliferation, apoptosis, metabolism, and differentiation.
  • Evidence strongly suggests the involvement of lncRNAs in the tumorigenesis and progression of multiple myeloma.

Conclusions:

  • lncRNAs are integral to the biological processes underlying multiple myeloma.
  • The established role of lncRNAs in MM development highlights their potential utility as biomarkers.
  • Further investigation into lncRNAs could lead to novel diagnostic and therapeutic strategies for multiple myeloma.
Keywords:
biomarkerlong non-coding RNAsmultiple myeloma

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